This book on urologic ultrasound has proven to be beneficial to urologists in training and currently in practice, and is structured by organ system for the practice of urology in the outpatient/office setting. The second edition expands on current techniques and procedures, includes ultrasound images, and gives new information on the use of ultrasound for the diagnosis and management of male reproductive conditions. The updated edition also discusses ultrasound in the intraoperative setting, chapters on male reproduction, ultrasound protocols, and standards for urologic practices performing ultrasound.
Bolstered with detailed illustrations and contributions from experts in the field, Practical Urologic Ultrasound, Second Edition is an authoritative and practical reference for all urologists worldwide in their mission to provide excellence in patient care.
This book provides an overview of pulmonary hypertensive diseases, the current understanding of their pathobiology, and a contemporary approach to diagnosis and treatment. It discusses the definition and classification of these disorders and the epidemiology of pulmonary arterial hypertension (PAH); explores the approach to diagnosis and evaluation via methods such as echocardiography, right heart catheterization, and cardiopulmonary exercise testing; describes the major drug classes used to treat PAH and the cell signaling pathways that they target as well as adjunct and investigative therapies; and highlights special situations that are particularly challenging in the management of PAH. Written by experts in their respective fields, Diagnosis and Management of Pulmonary Hypertension is a valuable resource for pulmonologists, cardiologists, and practitioners in internal medicine and critical care.
This volume offers the most comprehensive coverage on fetal programming. Chapters are written by authors of international and national standing, leaders in the field and trendsetters. The clinical relevance of the current research is emphasized in each chapter, which also contains key points, key words, and concise summaries for ease of learning. Fetal programming affects conditions in the immediate postnatal period, as well as in later life and adulthood. These conditions include cardiovascular disease, frank hypertension, stroke, dyslipidemia, coagulopathy, increased insulin resistance-metabolic syndrome, type-2 diabetes, leukemia, testicular cancer, prostate cancer, breast cancer, polycystic ovary syndrome, precocious puberty, impaired immune function, renal disease, lung disease, and osteoporosis. Neuropathologies, behavioral and mental deficiencies, schizophrenia, and depression have also been reported in adults who were exposed to nutritional inadequacies in utero. Diet, Nutrition and Fetal Programming provides an overview on the effects of fetal programming on disease, and comprehensive looks at maternal nutrition factors and fetal programming effects on brain and behavior, and physiology and disease. It also provides an in depth look at specific nutrient restrictions and supplements on physiology and disease, the effects of maternal disease on fetal programming, mechanisms of programming, and a special section on the international aspects and policies on fetal programming.
This volume explores the role free radicals and antioxidants within the development of vascular disease, examining fundamental research and translating preclinical knowledge to clinical trials. The expertly authored chapters describe the relationship of oxidative stress to atherosclerosis and the cardiovascular system, exploring its role in cardiac fibrosis, renovascular disease, hypertension, and regulation of blood pressure and cerebral vascular tone. The concluding chapter discusses the current state of clinical research, contextualizing clinical trials within the existing theoretical framework and analyzing attempts to preserve oxidant stress under various conditions.
With its concise and authoritative analysis of pre-clinical research and clinical results, Studies in Atherosclerosis - part of the bestselling Oxidative Stress in Basic Research and Clinical Practice series - is essential for researchers and clinicians focusing in cardiology, nephrology, or oxidative stress.
This comprehensive volume covers all aspects of nutrition in different scenarios of maternal diabetes, including the Type 1 or Type 2 diabetic mother, gestational diabetes, and postpartum diabetes. The volumes offer a comprehensive, yet thorough, overview of the subject, from the prevalence, risk factors, and insulin requirements of the mother; to possible outcomes and effects on the infant; to dietary advice in general and specific scenarios; and information on macro and micronutrient supplements. There is also a special section on international perspectives on maternal diabetes, with ten chapters that each focus on a different country.
Nutrition and Diet in Maternal Diabetes: An Evidence-Based Approach offers an overview of the Type 1 and type 2 diabetic mother, maternal and offspring aspects of gestation diabetes, and breastfeeding and maternal gestational diabetes.?
This book offers a practical guide to endovascular treatment of cerebrovascular disease and provides a concise reference for the related neurovascular anatomy and the various disorders that affect the vascular system. Fully revised and updated, the information is accessible and easy to read. It discusses fundamental principles underlying cerebral and spinal angiography; interventional techniques, devices, and practice guidelines; and commonly encountered cerebrovascular disorders for which interventional and endovascular methods are appropriate. New topics and features include: intracerebral and intraventricular hemorrhage; intracranial tumor embolization; vasculitis work-up and management; percutaneous carotid artery puncture technique; and pediatric aspects of neurointerventional techniques and disease states. Handbook of Cerebrovascular Disease and Neurointerventional Technique, 3rd Edition, is a portable and concise resource for interventional neuroradiologists, neurologists, neurosurgeons, cardiologists, and vascular surgeons.
This book addresses the unique sociocultural and historical systems of oppression that have alienated African-American and other racial minority patients within the mental healthcare system. This text aims to build a novel didactic curriculum addressing racism, justice, and community mental health as these issues intersect clinical practice. Unlike any other resource, this guide moves beyond an exploration of the problem of racism and its detrimental effects, to a practical, solution-oriented discussion of how to understand and approach the mental health consequences with a lens and sensitivity for contemporary justice issues. After establishing the historical context of racism within organized medicine and psychiatry, the text boldly examines contemporary issues, including clinical biases in diagnosis and treatment, addiction and incarceration, and perspectives on providing psychotherapy to racial minorities. The text concludes with chapters covering training and medical education within this sphere, approaches to supporting patients coping with racism and discrimination, and strategies for changing institutional practices in mental healthcare. Written by thought leaders in the field, Racism and Psychiatry is the only current tool for psychiatrists, psychologists, administrators, educators, medical students, social workers, and all clinicians working to treat patients dealing with issues of racism at the point of mental healthcare.
This book presents an up-to-date and comprehensive review of female contraception. It offers an extensive overview of contraception types, including oral, injectable, emergency, and various cervical barrier contraceptives, as well as behavioral and sterilization methods, and discusses the clinical effectiveness, advantages, disadvantages, side effects, and mechanisms of action of each method. Thoroughly revised and updated, the second edition includes coverage of chewable contraceptives, new progestins, new quadraphasic OCP regimen, Nexplanon, which is replacing the Implanon contraceptive implant, and new methods of tubal sterilization. There is also a new chapter devoted to current controversies. Each chapter also includes counseling tips that answer common questions many clinicians and patients have about contraception. The advances in contraception technologies are interplayed with practical advice on choosing the most effective and appropriate contraception for patients, from those who are young and healthy to those with serious medical diseases. The Handbook of Contraception, Second Edition, is an incomparable reference for obstetricians, gynecologists, and primary care physicians.
Asthma is a chronic relapsing airways disease that represents a major public health problem
worldwide. Intermittent exacerbations are provoked by airway mucosal exposure
to pro-inflammatory stimuli, with RNA viral infections or inhaled allergens representing
the two most common precipitants. In this setting, inducible signaling pathways
the airway mucosa play a central role in the initiation of airway inflammation
through production of antimicrobial peptides (defensins), cytokines, chemokines
and arachidonic acid metabolites that coordinate the complex processes of
vascular permeability, cellular recruitment, mucous hyper-secretion, bronchial
constriction and tissue remodeling.
These signals also are responsible for leukocytic infiltration into the
submucosa, T helper-lymphocyte skewing, and allergic sensitization.
Currently, it
is well appreciated that asthma is a heterogeneous in terms of onset,
exacerbants, severity, and treatment response.
Current asthma classification methods are largely descriptive and focus
on a single aspect or dimension of the disease.
An active area of investigation on how to collect, use and visualize multidimensional
profiling in asthma. This book will
overview multidimensional profiling strategies and visualization approaches for
phenotyping asthma. As an outcome, this
work will facilitate the understanding of disease etiology, prognosis and/or
therapeutic intervention. ?
During the last 30 years it has become clearly evident that oxidative stress and free radical biology play key roles in carcinogenesis, cancer progression, cancer therapy, and normal tissue damage that limits treatment efficacy during cancer therapy. These mechanistic observations have led to the realization that free radical biology and cancer biology are two integrally related fields of investigation that can greatly benefit from cross fertilization of theoretical constructs. The current volume of scientific papers was assembled under the heading of Oxidative Stress in Cancer Biology and Therapy in order to stimulate the discussion of how the knowledge gained in the emerging field of oxidative stress in cancer biology can be utilized to more effectively design interventions to enhance therapeutic responses while causing fewer treatment limiting complications. The chapters contained in this volume provide highly informative emerging perspectives on how that selective enhancement of oxidative stress in cancerous tissues can be used as a target for enhancing therapeutic outcomes as well as how selective inhibition of oxidative stress could spare normal tissue damage and inhibit carcinogenesis. In this regard, the book represents an outstanding resource for both basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy.
This volume will outline how to recreate the tumor microenvironment, to culture primary tumors without the need for developmental priming factors, and to deliver targeted therapeutics in a manner that recapitulates pharmacokinetics in vivo. Much of what may be learned from this volume will aid in understanding many aspects of the enhanced study of tumor cell biology in a physiologic context, open new avenues for drug screening and biomarker development, and accelerate the preclinical evaluation of novel personalized medicine strategies for patients in real time.
A wide variety of professionals find themselves intimately involved in the criminal justice system; firefighters, emergency medical providers, nurses, physicians, public health personnel, environmental professionals, public works personnel, and many others. No previous work has attempted to address the criminal justice system in terms relevant to these professionals. Interface: A Guide for Professionals Supporting the Criminal Justice System explains the system, provides the reader with guidance to documenting incidents so that the data is both of value to the professional in the future and for use by the other components of the system. Further, this volume presents evidence from the aspect of these professionals, their needs in handling evidence, and basics of collection and preservation for those instances where it falls to them to do so. Professionals, not familiar with safety issues outside of their fields of expertise, have been injured or died as a result of exposure to hazards; it also educates them to considerations for their safety when out of their area of comfort. In addition, this book considers the role of the professional as interviewer, and provides basic guidance to this often valuable skill. Finally, Interface attempts to make the professional knowledgeable and comfortable in the courts, especially on the stand, where the professional may appear as a witness or even as an expert.
This
text presents the application of current nutritional knowledge by physicians
and dietitians and incorporates emerging fields of science and important
discoveries. It contains seven major sections.
Section 1: Basic Processes at the Cellular Levels, Section 2: Arginine
Metabolism and Functions, Section 3: Arginine Status in Cells Related to Organ
Damage and Disease, Section 4: Arginine Status and Use in Healthy Individuals, Section
5: Arginine and Diseases of the Gastrointestinal Tract, Section 6: Therapeutic
uses of Arginine: Diabetes, Obesity and Cardiovascular Diseases and Section 7: Therapeutic Uses of Arginine: Cancer, Wound
Healing and Infectious Disease.
Written
by authors of international and national standing, leaders in the field and
trendsetters, Arginine in Clinical Nutrition is essential reading for
nutritionists and dietitians, public health scientists, doctors,
epidemiologists, health care professionals of various disciplines, policy
makers and marketing and economic strategists.
Medical research made huge strides in treating heart disease in the 20th
century, from drug-eluding stents to automatic internal defibrillators. Public awareness of the dangers of heart disease has never been more pervasive. Now, though, ten years into a new millennium, scientists are gearing up for the next great challenges in tackling this pervasive condition. Cell therapy is going to be a key weapon in the fight against heart disease. It has the potential to address many cardiovascular conditions. From heart failure to atrioventricular nodal dysfunction, the young but promising field of cell therapy is set to play a significant role in developing the cures that the upcoming decades of hard work will yield.
Regenerating
the Heart: Stem Cells and the Cardiovascular System organizes the field
into a digestible body of knowledge. Its four sections cover mechanical
regeneration, electrical regeneration, cardiac tissues and in vivo stem cell
therapies. An array of talented researchers share the fruits of their labors,
with chapters covering such crucial issues as the cardiogenic potential of
varying stem cell types, the ways in which they might be used to tackle
arrhythmias, their possible application to biological replacements for cardiac
tissues such as valves, and the varying approaches used in the in vivo
evaluation of stem cell therapies, including methods of delivering stem cells
to the myocardium.
This
comprehensive survey of an area of research with such exciting potential is an
invaluable resource both for veteran stem cell researchers who need to monitor
fresh developments, and for newly minted investigators seeking inspirational
examples.
A major portion of all of acute child neurology involves the neurological complications of infectious diseases. However, none of the currently available excellent texts on inf- tious disease focus specifically on the neurological aspects. Drs. Neil R. Friedman and Leslie L. Barton have filled this important void with a superb, multi-authored text, addressing directly "the neurological manifestations of pediatric infectious diseases and immunodeficiency syndromes. " The book is organized logically according to the responsible microorganisms and addresses sequentially a broad spectrum of viruses, bacteria, fungi, rickettsiae, spirochetes, mycobacteriae, and parasites, as well as cat-scratch disease and human immunodeficiency virus (HIV) infection. The chapters are consistently similar in organization and begin with an introduction that provides a synopsis and perspective. The substance of the chapters follows in sections devoted to epidemiology, pathog- esis, clinical manifestations, diagnosis, treatment, and references. The discussions of epidemiology are particularly informative and current. The sections on pathogenesis include valuable neuropathology and critical distinctions among disorders caused by primary infection by the microorganism and those related to parainfectious and postinfectious immunological phenomena. The sections on clinical manifestations emphasize the neurological features and often are subdivided into specific neurolo- cal syndromes. Results of modern brain imaging are illustrated, and tables highlight neurological and other features. Sections on diagnosis are especially valuable and emphasize the value of polymerase chain reaction (PCR) and related means of identifying microbial nucleic acids and proteins. The discussions of treatment areespecially current and valuable.
We dedicate this text to Drs. Ernest E. Aegerter, a pathologist, and John A. Kirkpatrick Jr., a radiologist. They were among the principal founders of the ?eld of skeletal pathology and radiology. During their time, their residents and colleagues knew them as great educators with a dedication and a passion for their work. Their textbook, Orthopedic Diseases, published initially in 1958 was among the ?rst interdisciplinary works devoted to this ?eld. Dr. Aegerter and Dr. Kirkpatrick illuminated many aspects of the ?eld of radiology. Today, with the advent of new technologies, this ?eld has grown to include not only diseases that affect the skeleton but also those that affect muscles, ligaments, tendons, and also the cartilaginous structures within joints. With this text we intend to carry on Dr. Aegerter and Dr. Kirkpatrick's tradition. We have recruited only well-known musculoskeletal radiologists and pathologists to participate in the writing of this book. Each author has been carefully selected for his expertise on the topic about which he's been asked to contribute. Each author is known as an experienced and seasoned teacher. Each author has made a mark on the ?eld.
The transplant physicians and surgeons at Cleveland Clinic have collaborated to produce, Kidney and Pancreas Transplantation: A Practical Guide. This volume is devoted to kidney and pancreas transplantation and is well grounded in scientific principles, quantitative clinical reasoning, clinical pharmacology, tested clinical practices and overall clinical applicability. Also addressed are key aspects in the initiation, maintenance and sustained growth of viable clinical programs in kidney and pancreas transplantation. Kidney and Pancreas Transplantation: A Practical Guide will be of great value to transplant physicians as well as medical and surgical fellows who intend to pursue an interest in transplantation.
The Evolving Concept of Oxidative Stress.- Mechanisms of Redox Signaling in Cardiovascular Disease.- Reactive Oxygen and Nitrogen Species in Cardiovascular Differentiation of Stem Cells.- Reactive Oxygen Species (ROS) and the Sensory Neurovascular Component.- Mitochondrial Reactive Oxygen Species in Myocardial Pre- and Postconditioning.- Coenzyme Q9/Q10 and the Healthy Heart.- Oxidative and Proteolytic Stress in Homocysteine-Associated Cardiovascular Diseases.- Functional Studies of NADPH Oxidases in Human Vasculature.- Relationship of the CYBA Gene Polymorphisms with Oxidative Stress and Cardiovascular Risk.- Redox-Related Genetic Markers of Cardiovascular Diseases.- NADPH Oxidases and Blood-Brain Barrier Dysfunction in Stroke.- Smoking-Induced Oxidative Stress in the Pathogenesis of Cardiovascular Diseases.- Oxidative Stress in Vascular Aging.- Oxidative Stress and Cardiovascular Disease in Diabetes Mellitus.- Reactive Oxygen Species, Oxidative Stress, and Hypertension.- Peripartum Cardiomyopathy: Role of STAT-3 and Reactive Oxygen Species.- Oxidative Stress and Inflammation after Coronary Angiography.- Oxidative Stress in Cardiac Transplantation.- Oxidative Stress and Atrial Fibrillation.- Oxidative Stress and the Antioxidative Capacity in Myocardial Infarction.- Oxidative Stress and Redox Signalling in Cardiac Remodelling.- Oxidative Stress and Cardiovascular Fibrosis.- Oxidative Risk Factors for Cardiovascular Disease in Women.- Protective Effects of Food on Cardiovascular Diseases.- Novel Synthetic Antioxidants and Nitrated Lipids: From Physiology to Therapeutic Implications.- Thioredoxin in the Cardiovascular System-Towards a Thioredoxin-Based Antioxidative Therapy.- The Protective Effect of Melatonin on the Heart.- Exercise-Induced Cardioprotection: Overviewwith an Emphasis on the Role of Antioxidants.- Antioxidative Properties of Statins in the Heart.
From the world renowned Fred Hutchinson Cancer Research Center, this book is written for all physicians who treat patients with acute or chronic leukemias or myelodysplasia. It is designed to answer questions about treatment approaches that commonly arise in day-to-day practice. In keeping with the Center's groundbreaking research in bone marrow transplantation, the book provides exceptional coverage of the role of allogeneic transplant in treatment. It also addresses the important issues of supportive care and long-term complications of successful treatment. oEdited and written by experts at the Fred Hutchinson Cancer Research Center
oClinically focused and comprehensive coverage of treatment approaches
oAllogeneic transplant addressed in detail
oSeparate chapters on supportive care and long-term complications
Advances over the past two decades have enabled physicians to revolutionize the manner in which they can assess and manage children's pain. Thirty years ago it was thought that young children did not experience pain and therefore it was not necessary to treat it. Today professionals from a variety of disciplines have contributed data that have revolutionized medical perspectives. Technological advances now enable doctors to treat acute pain in fetuses, premature neonates, infants, toddlers, children, and adolescents with increasing precision and efficacy. Research highlighting the context of chronic pain has moved them away from a mind-body dichotomy and toward an integrated, holistic perspective that leads to substantial improvement in children's adaptive functioning as well as subjective discomfort.
This book covers these topics and is intended for anyone who provides medical care to children. Each chapter provides an overview of the problem, followed by a "hands on" description of relevant assessment and intervention strategies. The role of the primary care practitioner is highlighted, both as a front-line resource as well as a consumer of specialized pediatric pain treatment services. Each chapter ends with a summary and specific bullet points highlighting the most central elements, making for quick and easy reference.
Nutrients, Dietary Supplements, and Nutriceuticals: Cost Analysis Versus Clinical Benefits provides the most current, concise, scientific appraisal and economic analysis (costs vs. benefit) of nutritional supplements and bioactive components (nutriceuticals) of foods in improving the quality of life. It fills a much-needed gap to have a single volume provide a synopsis of cost analysis of dietary supplements and nutritional products as well as therapies for treatment and prevention of disease. Chapters include emerging fields of science and important discoveries relating to early stages of new nutriceuticals in cancer prevention, prior to clinical trials.
Written by international and national standing leaders in the field, Nutrients, Dietary Supplements, and Nutriceuticals: Cost Analysis Versus Clinical Benefits is essential reading for nutritionists, pharmacologists, health care professionals, research scientists, cancer workers, pathologists, molecular and cellular biochemists, physicians, general practitioners as well as those interested in diet and nutrition in disease resistance via immune regulation.
Chronic alcohol use is associated with heart, liver, brain, and other organ pathology. Alcohol is a drug of abuse and a caloric food and it causes poor intake and absorption of nutrients, thus playing a major role in many aspects of clinical consequences. Alcohol use lowers consumption of fruit and vegetables, lowers tissue nutrients, and, in some cases, requires nutritional therapy by clinicians. Alcohol, Nutrition, and Health Consequences will help the clinician define the causes and types of nutritional changes due to alcohol use and also explain how nutrition can be used to ameliorate its consequences. Chapters present the application of current nutritional knowledge by physicians and dietitians. Specific areas involving alcohol-related damage due to nutritional changes are reviewed, including heart disease, obesity, digestive tract cancers, lactation, brain function, and liver disease. In addition, alcohol's effects on absorption of minerals and nutrients, a key role in causing damage are treated. The importance of diet in modifying alcohol and its metabolite damage is also explained. Alcohol, Nutrition, and Health Consequences is essential reading for alcohol therapists and researchers as well as primary care physicians and dietitians and is an easy reference to help the clinician, student, and dietitian comprehend the complex changes caused by direct and indirect effects of ethanol at the cellular level via its nutritional modification.
Magnesium is an essential mineral which is required for growth and survival of humans. Since magnesium is a mineral and not synthesizable it must be obtained through dietary foods and/or supplements. Magnesium in Human Health and Disease reviews the benefits of magnesium supplementation to reach recommended intakes as well as provides new research that suggests how reaching levels above the recommended intakes can promote health and treat various diseases. Magnesium deficiency can cause low serum potassium and calcium levels, retention of sodium, and low circulating levels of regulatory hormones. These changes in nutrients cause neurological and muscular symptoms such as tremor and muscle spasms. Further magnesium deficiency causes loss of appetite, nausea, vomiting, personality changes and death from heart failure. Causes of magnesium deficiency include alcohol abuse, poorly controlled diabetes, excessive or chronic vomiting and/or diarrhea. Thus the effects of inadequate and deficient intakes or levels of magnesium is critical to health and are reviewed by the expert clinicians in this book. Magnesium in Human Health and Disease provides the most current research to support the potential benefits or lack thereof for normal and high supplementation with magnesium. Animal model research and early human trials are reviewed to document other disease states such as hypertension, cholesterol level, type 2 diabetes and cardiovascular disease that would benefit from increased magnesium.
Now going into its third much-expanded edition, the highly praised Nutritional Health: Strategies for Disease Prevention has been brought fully up to date to include all the new thinking and discoveries that have the greatest capacity to improve human health and nutritional advancement. About half the new edition will be revised and updated from the second edition while the other half will consist of major revisions of previous chapters or new subjects. Like the two previous editions the book will consist of general reviews on various topics in nutrition, especially those of much current interest. The authors provide extensive, in-depth chapters covering the most important aspects of the complex interactions between diet, its nutrient components, and their impacts on disease states, and on those health conditions that increase the risk of chronic dieases. Up to date and comprehensive, Nutritional Health: Strategies for Disease Prevention, Third Edition offers physicians, dietitians, and nutritionists a practical, data-driven, integrated resource to help evaluate the critical role of nutrition.
