• London bid leader and British Olympic hero Sebastian Coe, Tony Blair and David Beckham all played a part in winning the most competitive race for the Games in Olympic history. But it was far from plain sailing and the campaign was a rollercoaster ride of emotions: full of drama, controversy and tears from the moment businesswoman Barbara Cassani was given the task of launching the bid in 2003, to the fateful day in Singapore when her successor, Lord Coe, and the rest of the world was told London had won.
    Mike Lee was at the heart of this intriguing journey through the entangled world of International Olympic Committee politics, international sport, British politics and the media as he travelled the world with Coe and other team members to present London's bid.

  • The still-unfolding story of America’s Constitution is a history of heroes and villains--the flawed visionaries who inspired and crafted liberty’s safeguards, and the shortsighted opportunists who defied them. Those stories are known by few today.In Our Lost Constitution, Senator Mike Lee tells the dramatic, little-known stories behind six of the Constitution’s most indispensible provisions. He shows their rise. He shows their fall. And he makes vividly clear how nearly every abuse of federal power today is rooted in neglect of this Lost Constitution. For example:
    • The Origination Clause says that all bills to raise taxes must originate in the House of Representatives, but contempt for the clause ensured the passage of Obamacare.
    • The Fourth Amendment protects us against unreasonable searches and seizures, but the NSA now collects our private data without a warrant.
    • The Legislative Powers Clause means that only Congress can pass laws, but unelected agencies now produce ninety-nine out of every one hundred pages of legal rules imposed on the American people.
    Lee’s cast of characters includes a former Ku Klux Klansman, who hijacked the Establishment Clause to strangle Catholic schools; the Chief Justice of the Supreme Court, who called the Second Amendment a fraud; and the revered president who began his first of four terms by threating to shatter the balance of power between Congress and the president, and who began his second term by vowing to do the same to the Supreme Court.
    Fortunately, the Constitution has always had its defenders. Senator Lee tells the story of how Andrew Jackson, noted for his courage in duels and politics, stood firm against the unconstitutional expansion of federal powers. He brings to life Ben Franklin’s genius for compromise at a deeply divided constitutional convention. And he tells how in 2008, a couple of unlikely challengers persuaded the Supreme Court to rediscover the Second Amendment’s right to keep and bear arms.
    Sections of the Constitution may have been forgotten, but it’s not too late to bring them back--if only we remember why we once demanded them and how we later lost them. Drawing on his experience working in all three branches of government, Senator Lee makes a bold case for resurrecting the Lost Constitution to restore and defend our fundamental liberties.
    From the Hardcover edition.

  • Some of America’s most important founders have been erased from our history books. In the fight to restore the true meaning of the Constitution, their stories must be told.
    In the earliest days of our nation, a handful of unsung heroes--including women, slaves, and an Iroquois chief--made crucial contributions to our republic. They pioneered the ideas that led to the Bill of Rights, the separation of powers, and the abolition of slavery. Yet, their faces haven’t been printed on our currency or carved into any cliffs. Instead, they were marginalized, silenced, or forgotten--sometimes by an accident of history, sometimes by design.
    In the thick of the debates over the Constitution, some founders warned about the dangers of giving too much power to the central government. Though they did not win every battle, these anti-Federalists and their allies managed to insert a system of checks and balances to protect the people from an intrusive federal government. Other forgotten figures were not politicians themselves, but by their thoughts and actions influenced America’s story. Yet successive generations have forgotten their message, leading to the creation of a vast federal bureaucracy that our founders would not recognize and did not want.
    Senator Mike Lee, one of the most consistent and impassioned opponents of an abusive federal government, tells the story of liberty’s forgotten heroes. In these pages, you’ll learn the true stories of founders such as...
    • Aaron Burr who is depicted in the popular musical Hamilton and in history books as a villain, but in reality was a far more complicated figure who fought the abuse of executive power.
    • Mercy Otis Warren, one of the most prominent female writers in the Revolution and a protégé of John Adams, who engaged in vigorous debates against the encroachment of federal power and ultimately broke with Adams over her fears of the Constitution.
    • Canasatego, an Iroquois chief whose words taught Benjamin Franklin the basic principles behind the separation of powers.
    The popular movement that swept Republicans into power in 2010 and 2016 was led by Americans who rediscovered the majesty of the Constitution and knew the stories of Hamilton, Madison, and Washington. But we should also know the names of the contrarians who argued against them and who have been written out of history. If we knew of the heroic fights of these lost founders, we’d never have ended up with a government too big, too powerful, and too unresponsive to its citizens. The good news is that it’s not too late to rememberand to return to our first principles. Restoring the memory of these lost individuals will strike a crippling blow against big government.

  • À regarder les photographies de Mike Lee on ne peut deviner qui habite qui. Est ce la ville qui abrite et protège l'homme, est-ce elle qui l'aide à se développer, ou est-ce lui qui la nourrit ? L'objectif de Mike Lee croise des solitudes dans une fourmilière qui semble avoir oublier son nombre.
    When looking at Mike Lee's pictures, one cannot guess who inhabits whom. Is the city protecting men and giving him shelter, is it helping him grow or on the contrary is he he who feeds the city ? Mike Lee's camera meets loneliness inside an anthill that seems to have forgotten how really numerous it is.

    www.corridorelephant.com

  • Spider-Man affronte son nouvel adversaire Tracer, tandis que Morlun projette de le détruire. Le Tisseur est également tourmenté par de terribles cauchemars, torturé par l'angoisse, convaincu d'être traqué. La vie du Monte-en-l'air devient un enfer et, cette fois, il se pourrait que l'ennemi à affronter soit trop fort, même pour lui. Est-ce la fin de Peter Parker ? Une chose est sûre, le crossover L'Autre changera à jamais le destin du plus célèbre personnage Marvel. J. Michael Straczynski, Peter David et Reginald Hudlin, accompagnés des fabuleux artistes Mike Wieringo, Pat Lee et Mike Deodato Jr, font sortir Peter Parker de sa zone de confort.

  • Changement climatique, biodiversité, énergie fossile, antibiotiques, plastique, nourriture... La liste des préoccupations écologiques est interminable. Mais quelle est la plus urgente ? Quelles sont les conséquences de nos actions et que devons-nous faire en premier lieu ? Faut-il devenir végétariens ? Arrêter de prendre l'avion ? Et, étant donné la nature mondiale des défis auxquels nous sommes désormais confrontés, sur quoi avons-nous réellement un impact ?
    Mike Berners-Lee envisage les solutions possibles et propose un plan d'action réaliste, aussi concret qu'instructif. Organisé sous la forme de questions-réponses, ce livre aborde toutes les thématiques actuelles : alimentation, climat, énergie, transport, économie, population, technologie et éthique. Par le biais d'analyses et de faits étonnants, il offre une vue d'ensemble des défis environnementaux, sociaux et économiques ainsi que des possibilités que nous avons pour y faire face.
    Laissez-vous inspirer et trouvez ce qui peut faire de vous, à votre échelle, un acteur du changement...

  • From a text message to a war, from a Valentine's rose to a flight or even having a child, How Bad are Bananas? gives us the carbon answers we need and provides plenty of revelations. By talking through a hundred or so items, Mike Berners-Lee sets out to give us a carbon instinct for the footprint of literally anything we do, buy and think about. He helps us pick our battles by laying out the orders of magnitude. The book ranges from the everyday (foods, books, plastic bags, bikes, flights, baths...) and the global (deforestation, data centres, rice production, the World Cup, volcanoes, ...) Be warned, some of the things you thought you knew about green living may be about to be turned on their head. Never preachy but packed full of information and always entertaining.

  • NIEPCEBOOK N°02 - Version numérique (PDF)
    NiepceBook n'est ni un livre, ni un magazine mais la rencontre des deux. 10 photographes, 11 chapitres, 276 pages, 1,2 kg. Livre-objet il offre des photographies pleine page, des interviews et un contenu sans publicité. Niepcebook n'est pas distribué en kiosque. NiepceBook publie des photographes contemporains issus d'horizons divers.

    Et si vous commenciez une collection ?

  • Mass Spectrometry Handbook

    Mike S. Lee

    • Wiley
    • 13 Avril 2012

    Due to its enormous sensitivity and ease of use, mass spectrometry has grown into the analytical tool of choice in most industries and areas of research. This unique reference provides an extensive library of methods used in mass spectrometry, covering applications of mass spectrometry in fields as diverse as drug discovery, environmental science, forensic science, clinical analysis, polymers, oil composition, doping, cellular research, semiconductor, ceramics, metals and alloys, and homeland security. The book provides the reader with a protocol for the technique described (including sampling methods) and explains why to use a particular method and not others. Essential for MS specialists working in industrial, environmental, and clinical fields.

  • New strategies and techniques for today's fast-paced discovery process
    Today, the pressure is on for high-throughput approaches to accelerate the generation, identification, and optimization of molecules with desirable drug properties. As traditional methods of analysis become antiquated, new analytical strategies and techniques are necessary to meet sample throughput requirements and manpower constraints. Among them, mass spectrometry has grown to be a front-line tool throughout drug discovery.
    Integrated Strategies for Drug Discovery Using Mass Spectrometry provides a thorough review of current analytical approaches, industry practices, and strategies in drug discovery. The topics represent current industry benchmarks in specific drug discovery activities that deal with proteomics, biomarker discovery, metabonomic approaches for toxicity screening, lead identification, compound libraries, quantitative bioanalytical support, biotransformation, reactive metabolite characterization, lead optimization, pharmaceutical property profiling, sample preparation strategies, and automation.
    THIS BOOK:
    * Clearly explains how drug discovery and mass spectrometry are interconnected
    * Discusses the uses and limitations of various types of mass spectrometry in various aspects of drug discovery
    * Prominently features analytical applications that require trace-mixture analysis
    * Provides industry applications and real-world examples
    * Shares historical background information on various techniques to aid in the understanding of how and why new methods are now being employed to analyze samples

  • Presents Practical Applications of Mass Spectrometry for Protein Analysis and Covers Their Impact on Accelerating Drug Discovery and Development Covers both qualitative and quantitative aspects of Mass Spectrometry protein analysis in drug discovery Principles, Instrumentation, Technologies topics include MS of peptides, proteins, and ADCs , instrumentation in protein analysis, nanospray technology in MS protein analysis, and automation in MS protein analysis Details emerging areas from drug monitoring to patient care such as Identification and validation of biomarkers for cancer, targeted MS approaches for biomarker validation, biomarker discovery, and regulatory perspectives Brings together the most current advances in the mass spectrometry technology and related method in protein analysis

  • Breakthroughs in combinatorial chemistry and molecular biology, as well as an overall industry trend toward accelerated development, mean the rate of sample generation now far exceeds the rate of sample analysis in the pursuit of producing new and better pharmaceuticals. LC/MS is an analytical tool that helps the researcher identify the most promising sample early in the selection process, effectively creating a shortcut to finding new drugs. This book is the first to describe LC/MS applications within the context of drug development, including the discovery, preclinical, clinical, and manufacturing phases.
    In addition to the thorough technical analysis of this tool, LC/MS Applications in Drug Development provides perspective on the significant changes in strategies for pharmaceutical analysis. A process overview of drug development from an analytical point of view is provided along with essential data required to successfully bring a drug to market. The incorporation of LC/MS is illustrated from target to product. Chapters pertaining to the discovery process itself include: Proteomics Glycoprotein Mapping Natural Products Dereplication Lead Identification Screening Open-Access LC/MS In Vitro Drug Screening Written for both the analytical chemist who uses LC/MS applications and the pharmaceutical scientist who works with the drugs they produce, LC/MS Applications in Drug Development is the premier reference on the subject.

  • This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to those in the industry. The authors have worked closely together and combine complementary backgrounds to bring technical and cultural awareness to this very important endeavor while serving to address needs within academia and industry It also contains a variety of problem sets following specific sections in the text.

  • Dried Blood Spots

    ,

    • Wiley
    • 12 Mai 2014

    An informative and comprehensive book on the applications and techniques of dried blood spot sampling Dried blood spot (DBS) sampling involves the collection of a small volume of blood, via a simple prick or other means, from a study subject onto a cellulose or polymer paper card, which is followed by drying and transfer to the laboratory for analysis. For many years, this method of blood sample collection has been extensively utilized in some important areas of human healthcare (for example, newborn screening for inherited metabolic disorders and HIV-related epidemiological studies). Because of its advantages over conventional blood, plasma, or serum sample collection, DBS sampling has been valued by the pharmaceutical industry in drug research and development. Dried Blood Spots: Applications and Techniques features contributions from an international team of leading scientists in the field. Their contributions present a unique resource on the history, principles, procedures, methodologies, applications, and emerging technologies related to DBS. Presented in three parts, the book thoroughly examines: Applications of DBS sampling and associated procedures and methodologies in various human healthcare studies Applications and perspectives of DBS sampling in drug research and development, and therapeutic drug monitoring New technologies and emerging applications related to DBS sampling and analysis Dried Blood Spots: Applications and Techniques is a valuable working guide for researchers, professionals, and students in healthcare, medical science, diagnostics, clinical chemistry, and pharmaceuticals, etc.

  • A proven approach to revenue-generating marketing and client development Professional Services Marketing is a fully field-tested and research-based approach to marketing and client development for professional services firms. The book, now in its Second Edition, covers five key areas that are critical for firms that want to grow and become more profitable: creating a marketing and growth strategy; establishing a brand and reputation; implementing a marketing communications program; executing lead generation strategies; and developing business by winning new clients. You will also read real-world case studies that illustrate major points, as well as quotes and stories from well-respected professionals in the industry. The Second Edition features new research and updates throughout, including new chapters on social media and online marketing, as well as new case studies and interviews Authors Mike Schultz and John E. Doerr are the coauthors of the Wall Street Journal and Inc. Magazine bestseller Rainmaking Conversations and Professional Services Marketing; Lee W. Frederiksen is coauthor of Online Marketing for Professional Services Will be widely promoted via multiple online routes and direct mail marketing Firms of any size can use this proven approach to marketing and client development to attract new clients and grow their professional service businesses.

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